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Adagio protein 3 (ADO3), Recombinant Protein
Cat: RP01698
Species: Arabidopsis thaliana (Mouse-ear cress)
Datasheet:
Product Info
Full Product Name
Recombinant Arabidopsis thaliana Adagio protein 3 (ADO3) , partial
Product Gene Name
ADO3 recombinant protein
Product Synonym Gene Name
ADO3
Purity
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Molecular Weight
69,063 Da
Storage
Store at -20℃. For long-term storage, store at -20℃ or -80℃. Store working aliquots at 4℃ for up to one week. Repeated freezing and thawing is not recommended.
Protein Family
Adagio protein
NCBI/Uniprot Data
NCBI Accession #
NP_564919.1
NCBI GI #
18408929
NCBI GenBank Nucleotide #
NM_105475.4
NCBI GeneID
843133
NCBI Official Full Name
flavin-binding, kelch repeat, f box 1
NCBI Official Symbol
FKF1
NCBI Official Synonym Symbols
''flavin-binding; ADO3; f box 1; f box 1''; flavin-binding; kelch repeat; T23K23.10; T23K23_10
NCBI Protein Information
flavin-binding, kelch repeat, f box 1
NCBI Summary
Encodes FKF1, a flavin-binding kelch repeat F box protein, is clock-controlled, regulates transition to flowering. Forms a complex with GI on the CO promoter to regulate CO expression.
UniProt Gene Name
ADO3
UniProt Synonym Gene Names
FKF1; FBX2a
UniProt Protein Name
Adagio protein 3
UniProt Synonym Protein Names
F-box only protein 2a; FBX2a; Flavin-binding kelch repeat F-box protein 1
UniProt Primary Accession #
Q9C9W9
UniProt Secondary Accession #
Q9M648
UniProt Related Accession #
Q9C9W9
UniProt Comments
Component of an E3 ubiquitin ligase complex that plays a central role in blue light-dependent circadian cycles. Acts as a blue light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex. The SCF(ADO3) E3 ubiquitin ligase complex is involved in the regulation of circadian clock-dependent processes including transition to flowering time, hypocotyl elongation, cotyledons and leaf movement rhythms. Forms a complex with 'GIGANTEA' (GI) to regulate 'CONSTANS' (CO) expression. Promotes CO expression during the light period of long days by decreasing the stability of CDF1 and CDF2 and by interacting directly with the CO protein and stabilizing it. ADO3 function is mainly GI dependent. Does not act as a regulator of CDF1 transcription. The interactions of ADO1/ZTL and ADO2 with ADO3 prevent its interaction with CDF1.
For research use only, not for clinical use.