NCBI Accession #
NP_190752.1
NCBI GenBank Nucleotide #
NM_115043.3
NCBI Official Full Name
acyl-CoA oxidase 4
NCBI Official Symbol
ACX4
NCBI Official Synonym Symbols
acyl-CoA oxidase 4; ATG6; ATSCX; SHORT-CHAIN ACYL COA OXIDASE
NCBI Protein Information
acyl-CoA oxidase 4
NCBI Summary
Encodes a short-chain acyl-CoA oxidase, which catalyzes the first step of peroxisomal fatty acid beta-oxidation during early, post-germinative growth in oilseed species. Null mutants virtually lack short-chain acyl-CoA and are resistant to 2,4-dichlorophenoxybutyric acid, which is converted to the herbicide and auxin analogue 2,4-dichlorophenoxyacetic acid by beta-oxidation. Despite the almost complete loss of short-chain activity, lipid catabolism and seedling growth and establishment was unaltered in the acx4 mutant. However, double mutants in acx3acx4 (acx3 encodes medium chain acyl CoA oxidase) were not viable and arrested during embryogenesis.
UniProt Synonym Gene Names
G6; AOX 4; AtCX4; AtG6; SAOX
UniProt Protein Name
Acyl-coenzyme A oxidase 4, peroxisomal
UniProt Synonym Protein Names
G6p; Short-chain acyl-CoA oxidase; AtCX4; AtG6; SAOX
UniProt Primary Accession #
Q96329
UniProt Related Accession #
Q96329
UniProt Comments
Catalyzes the desaturation of short-chain acyl-CoAs to 2-trans-enoyl-CoAs. Active on butyryl-CoA (C4), hexanoyl-CoA (C6), and octanoyl-CoA (C8). Has no activity as acyl-CoA dehydrogenase or on crotonyl-CoA (an unsaturated C4:1 carbocyclic ester) or glutaryl-CoA (a dicarboxylic ester).