NCBI Accession #
NP_178634.2
NCBI GenBank Nucleotide #
NM_126589.3
NCBI Official Full Name
aconitase 3
NCBI Official Symbol
ACO3
NCBI Official Synonym Symbols
aconitase 3; T3P4.5; T3P4_5
NCBI Protein Information
aconitase 3
NCBI Summary
Encodes an aconitase that can catalyze the conversion of citrate to isocitrate through a cis-aconitate intermediate, indicating that it may participate in the TCA cycle and other primary metabolic pathways. The protein is believed to accumulate in the mitochondria and the cytosol. It affects CSD2 (At2g28190 - a superoxide dismutase) transcript levels and may play a role in the response to oxidative stress. One member of the family (ACO1 - At35830) was shown to specifically bind to the 5' UTR of CSD2 in vitro. ACO3 is tyrosine-phosphorylated and its phosphorylation state is modulated in response to ABA in Arabidopsis thaliana seeds.
UniProt Synonym Gene Names
mACO1
UniProt Protein Name
Aconitate hydratase 3, mitochondrial
UniProt Synonym Protein Names
Citrate hydro-lyase 3
UniProt Primary Accession #
Q9SIB9
UniProt Secondary Accession #
Q8L784
UniProt Related Accession #
Q9SIB9
UniProt Comments
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. Contributes to oxidative stress tolerance (PubMed:17013749). Modulates cytosolic citrate metabolism during lipid mobilization. Required during seedling growth (PubMed:25061985).