5-hmC | 5-hydroxymethylcytosine (monoclonal)

Close structural similarity between 5-mC and 5-hmC makes them very difficult to expreimentally distinuish. Therefore affinity-based technology is employed to purify 5-hmC specific antibodies. This antibody is affinity purified and provided in PBS pH 7.4 with 0.05 % sodium azide.

5-methylol cytosine is a recently discovered DNA modification resulting from the conversion of 5-methylcytosine to 5-methylol cytosine by the TET oxygenase family. It may have an important role different from 5-methylcytosine (5-mC). The 5-hmC bases have been found in Purkinje neurons, granulosa cells, and embryonic stem cells, and they are present in Purkinje cells at high levels (up to 0.6% of the total nucleotides in Purkinje cells).