NCBI Accession #
NP_176686.1
NCBI GenBank Nucleotide #
NM_105180.4
NCBI Official Full Name
4-coumarate:CoA ligase 3
NCBI Official Symbol
4CL3
NCBI Official Synonym Symbols
4-COUMARATE:COA LIGASE; 4-coumarate:CoA ligase 3; F16G16.6; F16G16_6
NCBI Protein Information
4-coumarate:CoA ligase 3
NCBI Summary
encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. mRNA levels are not induced in response to wounding or to fungal infection by P. parasitica. mRNA is expressed in flowers, to a lesser degree in mature leaves and siliques and marginally in seedling roots and bolting stems of mature plants. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, ferulic acid, cinnamic acid and 5-OH-ferulic acid. At4CL3 was unable to use sinapic acid as substrate.
UniProt Synonym Gene Names
4CL 3; At4CL3
UniProt Protein Name
4-coumarate--CoA ligase 3
UniProt Synonym Protein Names
4-coumarate--CoA ligase isoform 3; At4CL3; 4-coumaroyl-CoA synthase 3
UniProt Primary Accession #
Q9S777
UniProt Secondary Accession #
Q93Z69
UniProt Related Accession #
Q9S777
UniProt Comments
Produces CoA thioesters of a variety of hydroxy- and methoxy-substituted cinnamic acids, which are used to synthesize several phenylpropanoid-derived compounds, including anthocyanins, flavonoids, isoflavonoids, coumarins, lignin, suberin and wall-bound phenolics.