NCBI Accession #
NP_188761.1
NCBI GenBank Nucleotide #
NM_113019.4
NCBI Official Full Name
4-coumarate:CoA ligase 2
NCBI Official Symbol
4CL2
NCBI Official Synonym Symbols
4-COUMARATE:COA LIGASE; 4-coumarate:CoA ligase 2; AT4CL2
NCBI Protein Information
4-coumarate:CoA ligase 2
NCBI Summary
encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, ferulic acid, 5-OH-ferulic acid and cinnamic acid. At4CL2 was unable to use sinapic acid as substrate.
UniProt Synonym Gene Names
4CL 2; At4CL2
UniProt Protein Name
4-coumarate--CoA ligase 2
UniProt Synonym Protein Names
4-coumarate--CoA ligase isoform 2; At4CL2; 4-coumaroyl-CoA synthase 2
UniProt Primary Accession #
Q9S725
UniProt Secondary Accession #
Q53Z06; Q56ZS8; Q9LU35
UniProt Related Accession #
Q9S725
UniProt Comments
Produces CoA thioesters of a variety of hydroxy- and methoxy-substituted cinnamic acids, which are used to synthesize several phenylpropanoid-derived compounds, including anthocyanins, flavonoids, isoflavonoids, coumarins, lignin, suberin and wall-bound phenolics.