NCBI Accession #
NP_180232.1
NCBI GenBank Nucleotide #
NM_128221.5
NCBI Official Full Name
3-ketoacyl-CoA synthase 11
NCBI Official Symbol
KCS11
NCBI Official Synonym Symbols
3-ketoacyl-CoA synthase 11; F18A8.1; F18A8_1; KCS11
NCBI Protein Information
3-ketoacyl-CoA synthase 11
NCBI Summary
Encodes KCS11, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
UniProt Synonym Gene Names
KCS-11
UniProt Protein Name
3-ketoacyl-CoA synthase 11
UniProt Synonym Protein Names
Very long-chain fatty acid condensing enzyme 11
UniProt Entry Name
KCS11_ARATH
UniProt Primary Accession #
O48780
UniProt Related Accession #
A84663
UniProt Comments
Function: Active on both saturated and mono-unsaturated acyl chains C16 to C20.Catalytic activity: Stearoyl-CoA + malonyl-CoA + 2 NAD(P)H = icosanoyl-CoA + CO2 + CoA + 2 NAD(P)+ + H2O.A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.Pathway: Lipid metabolism; fatty acid biosynthesis.Subcellular location: Membrane; Multi-pass membrane protein Potential. Tissue specificity: Only expressed in guard cells.Induction: Repressed by herbicides such as flufenacet and benfuresate.Sequence similarities: Belongs to the chalcone/stilbene synthases family.Contains 1 FAE (fatty acid elongase) domain.