Phospho-Tau (Thr231) Antibody - CD BioSciences

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Phospho-Tau (Thr231) Antibody

Phospho-Tau (Thr231) Antibody

SPA-10619

Size Price
0.05 mL Online Inquiry
0.025 mL Online Inquiry
More Options Online Inquiry
Target Information
Target Name Tau
Gene Abbr. MAPT
Gene ID 4137
Full Name microtubule associated protein tau
Alias DDPAC, FTDP-17, MAPTL, MSTD, MTBT1
Introduction Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau.
Product Details
Host Rabbit
Clonality Monoclonal
Clone No. SC58-08
Isotype IgG
Immunogen Synthetic phospho-peptide surrounding T231 of Tau.
Usage
Application WB, IHC, IP
Dilutions Western Blot (1:100-1:2000); Immunohistochemistry (1:10-1:500)
Reactivity Human, Mouse, Rat
Storage & Handling
Storage Buffer TBS (pH 7.4), 1% BSA, 40% Glycerol.
Preservative 0.05% Sodium Azide
Storage Temp. Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.