Phospho-SAPK/JNK (Thr183/Tyr185) Sandwich ELISA Antibody Pair - CD BioSciences

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Phospho-SAPK/JNK (Thr183/Tyr185) Sandwich ELISA Antibody Pair

Phospho-SAPK/JNK (Thr183/Tyr185) Sandwich ELISA Antibody Pair

SPK-00979

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1 X 96T Online Inquiry
5 X 96T Online Inquiry
10 X 96T Online Inquiry
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Target Information
Target Name SAPK/JNK2
Gene Abbr. MAPK9
Gene ID 5601
Full Name mitogen-activated protein kinase 9
Alias JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B
Introduction The stress-activated protein kinase/Jun-amino-terminal kinase SAPK/JNK is potently and preferentially activated by a variety of environmental stresses including UV and gamma radiation, ceramides, inflammatory cytokines, and in some instances, growth factors and GPCR agonists. As with the other MAPKs, the core signaling unit is composed of a MAPKKK, typically MEKK1-MEKK4, or by one of the mixed lineage kinases (MLKs), which phosphorylate and activate MKK4/7. Upon activation, MKKs phosphorylate and activate the SAPK/JNK kinase. Stress signals are delivered to this cascade by small GTPases of the Rho family (Rac, Rho, cdc42). Both Rac1 and cdc42 mediate the stimulation of MEKKs and MLKs. Alternatively, MKK4/7 can be activated in a GTPase-independent mechanism via stimulation of a germinal center kinase (GCK) family member. There are three SAPK/JNK genes each of which undergoes alternative splicing, resulting in numerous isoforms. SAPK/JNK, when active as a dimer, can translocate to the nucleus and regulate transcription through its effects on c-Jun, ATF-2, and other transcription factors.
Product Details
Measurement Sandwich
Usage
Application ELISA
Reactivity
Sensitivity For Antibody Pair specificity and sensitivity, please refer to the corresponding Sandwich ELISA Kit.
Storage & Handling
Storage Temp. Capture and detection antibodies are stored at 4°C. HRP-linked secondary reagent is stored at -20°C.

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