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Phospho-PKCδ (Ser645) Antibody
SPA-08983
| Size | Price |
| 0.05 mL | Online Inquiry |
| 0.025 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | PKC |
| Gene Abbr. | PRKCD |
| Gene ID | 5580 |
| Full Name | protein kinase C delta |
| Alias | ALPS3, CVID9, MAY1, PKCD, nPKC-delta |
| Introduction | Protein Kinase C delta (PKC delta) is a 78 kDa member of the novel group (nPKCs: sensitive to diacylglycerol, phosphatidylserine, and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC delta is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of multiple cellular processes including cell cycle progression and apoptosis. Autophosphorylation of serine 664 (serine 662 in mouse and rat) contributes to PKC delta activity. Serum dependent phosphorylation of serine 664 is mediated by mTOR pathway, is protected from dephosphorylation by phosphorylated threonine 505 in the activation loop, and is implicated in prolactin signaling. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Synthesized phosphopeptide derived from human PKC delta around the phosphorylation site of serine 645 (R-L-SP-Y-S). |
| Usage | |
|---|---|
| Application | WB, IHC |
| Dilutions | Western Blot (1:500-1:1000) |
| MW(KDa) | 77 |
| Reactivity | Human, Mouse, Rat |
| Specificity | PKC delta (specific to Phospho-Ser645) detects endogenous levels of PKC delta only when phosphorylated at serine 645. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS (without Mg2+, Ca2+) (pH 7.4), 150 mM NaCl, 50% Glycerol. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.