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Phospho-Insulin Receptor Heterotetramer (Tyr1136/Tyr1163/Tyr1135/Tyr1162)Antibody
SPA-06030
| Size | Price |
| 25 µg | Online Inquiry |
| 50 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | InsR |
| Gene Abbr. | INSR |
| Gene ID | 3643 |
| Full Name | insulin receptor |
| Alias | CD220, HHF5 |
| Introduction | The heterotetrameric receptors for insulin (INS R) and IGF-I (IGF-I R) are receptor tyrosine kinases that consist of two ligand-binding alpha subunits and two beta subunits. Ligand binding induces autophosphorylation on multiple tyrosine residues of beta subunits. Phosphorylation of Tyr1162 and 1163 on INS R and Tyr1135 and 1136 on IGF‑I R stimulates intrinsic kinase activity. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Phosphopeptide containing human Insulin R Y1162/Y1163 sites. |
| Usage | |
|---|---|
| Application | WB, FC, IF |
| Dilutions | Western Blot (0.5 µg/mL); Immunofluorescence (5-15 µg/mL); Flow Cytometry (2.5 µg/10^6 cells) |
| Reactivity | Human |
| Specificity | Detects human Insulin R dually phosphorylated at Y1162 and Y1163, and human IGF-I R dually phosphorylated at Y1135 and Y1136. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.