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Phospho-IGF-I Receptor β (Tyr1131) Sandwich ELISA Antibody Pair
SPK-00527
| Size | Price |
| 1 X 96T | Online Inquiry |
| 5 X 96T | Online Inquiry |
| 10 X 96T | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | IGF Receptor |
| Gene Abbr. | IGF1R |
| Gene ID | 3480 |
| Full Name | insulin like growth factor 1 receptor |
| Alias | CD221, IGFIR, IGFR, JTK13 |
| Introduction | Type I insulin-like growth factor receptor (IGF-IR) is a transmembrane receptor tyrosine kinase that is widely expressed in many cell types in fetal and postnatal tissues, and which is highly similar in sequence and structure to the insulin receptor. IGF-IR is synthesized as a preproprotein which is proteolytically cleaved into alpha and beta subunits. Receptor assembly involves heterodimerization of two alpha and two beta subunits to generate the heterotetrameric transmembrane receptor. The alpha subunits form the extracellular ligand binding domain; ligand binding by IGF-I or IGF-II initiates autophosphorylation of conserved intracellular residues in the beta subunit kinase domain, leading to kinase activation and subsequent activation of downstream signal transduction pathways (e.g., Akt and MAPK). Enhanced mitogenic signaling through the IGF1R is frequently observed in cancer, making the IGF-IR an important research target in translational oncology. |
| Product Details | |
|---|---|
| Measurement | Sandwich |
| Usage | |
|---|---|
| Application | ELISA |
| Reactivity | |
| Sensitivity | For Antibody Pair specificity and sensitivity, please refer to the corresponding Sandwich ELISA Kit. |
| Storage & Handling | |
|---|---|
| Storage Temp. | Capture and detection antibodies are stored at 4°C. HRP-linked secondary reagent is stored at -20°C. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.