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Phospho-HS1 (Tyr397) Antibody
SPA-05255
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | HS1 |
| Gene Abbr. | HCLS1 |
| Gene ID | 3059 |
| Full Name | hematopoietic cell-specific Lyn substrate 1 |
| Alias | CTTNL, HS1, lckBP1, p75 |
| Introduction | HS1 (HCLS1, LckBP1, p75) is a protein kinase substrate that is expressed only in tissues and cells of hematopoietic origin. HS1 contains four cortactin repeats and a single SH3 domain. This intracellular protein is phosphorylated following immune receptor activation, which promotes recruitment of HS1 to the immune synapse. Phosphorylation of HS1 is required to regulate actin dynamics and provide docking sites for many other signaling molecules, such as Vav1 and PLCγ1. HS1 also plays an important role in platelet activation. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Immunogen | Detailed sequence is available upon request. |
| Usage | |
|---|---|
| Application | WB, IP |
| Dilutions | Western Blot (1:1000); Immunoprecipitation (1:50) |
| MW(KDa) | 80 |
| Sensitivity | Endogenous |
| Storage & Handling | |
|---|---|
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA and 50% glycerol. |
| Preservative | No Preservative |
| Storage Temp. | Store at -20 °C. |
| Handling | Do not aliquot the antibody. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.