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Phospho-FRS2-α (Tyr436) Antibody
SPA-04161
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | FRS2 |
| Gene Abbr. | FRS2 |
| Gene ID | 10818 |
| Full Name | fibroblast growth factor receptor substrate 2 |
| Alias | FRS1A, FRS2A, FRS2alpha, SNT, SNT-1 |
| Introduction | Fibroblast growth factor receptor substrate 2 (FRS2, also called Suc-associated neurotrophic factor-induced tyrosine-phosphorylated target or SNT) participates in the transmission of extracellular signals from the fibroblast growth factor receptor (FGFR). Activation of the FGFR leads to tyrosine phosphorylation of FRS2. Two FRS2 family members have been identified, FRS2-alpha (SNT1) and FRS2-beta (SNT2) which are phosphorylated by these RTKs. Once they are phosphorylated, they recruit SH2 domain-containing proteins including Grb2 and SHP-2, mediating downstream signaling. Tyr436 is required for efficient SHP-2 recruitment whereas Tyr196 functions as a docking site for Grb2-Sos complexes. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Phosphopeptide containing human FRS2 Y436 site. |
| Usage | |
|---|---|
| Application | WB, IF |
| Dilutions | Western Blot (1 µg/mL); Immunofluorescence (5-15 µg/mL) |
| MW(KDa) | 80-85 |
| Reactivity | Human, Mouse, Rat |
| Specificity | Detects human, mouse, and rat FRS2 isoforms when phosphorylated at Y436. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.