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Phospho-FAK (Tyr861) Antibody
SPA-03783
| Size | Price |
| 0.025 mL | Online Inquiry |
| 100 µL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | FAK |
| Gene Abbr. | PTK2 |
| Gene ID | 5747 |
| Full Name | protein tyrosine kinase 2 |
| Alias | FADK, FAK, FAK1, FRNK, PPP1R71 |
| Introduction | Focal adhesion kinase (FAK) is a widely expressed cytoplasmic protein tyrosine kinase involved in integrin-mediated signal transduction. It plays an important role in the control of several biological processes, including cell spreading, migration, and survival. Activation of FAK by integrin clustering leads to autophosphorylation at Tyr397, which is a binding site for the Src family kinases PI3K and PLCγ. Recruitment of Src family kinases results in the phosphorylation of Tyr407, Tyr576, and Tyr577 in the catalytic domain, and Tyr871 and Tyr925 in the carboxy-terminal region of FAK. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Chemically synthesized phosphopeptide obtained from the region of human FAK that contains Tyr861. The sequence is conserved in mouse, rat, chicken and frog. |
| Usage | |
|---|---|
| Application | WB, IF, IHC |
| Dilutions | Western Blot (1:1000); Immunofluorescence (1 µg/mL); Immunohistochemistry (1:10-1:500) |
| MW(KDa) | 125 |
| Reactivity | Human, Mouse, Chicken |
| Storage & Handling | |
|---|---|
| Storage Buffer | Dulbecco's PBS, pH 7.3, with 50% glyceroll and 1 mg/mL BSA. |
| Preservative | 0.05% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.