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PARP Antibody
SPA-08609
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | PARP |
| Gene Abbr. | PARP1 |
| Gene ID | 142 |
| Full Name | poly(ADP-ribose) polymerase 1 |
| Alias | ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP |
| Introduction | PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | C2-10 |
| Isotype | IgG1 |
| Immunogen | Full length calf thymus poly(ADP-ribose) polymerase (PARP). |
| Usage | |
|---|---|
| Application | WB, IF |
| MW(KDa) | 89, 116 |
| Reactivity | Multi-species |
| Specificity | This antibody recognizes both the full length (116 kDa) and 85 kDa cleavage fragment of PARP in human, monkey, mouse, rat, bovine and hamster systems. Chicken PARP is not recognized. Other species have not been tested. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS with 0.2% BSA and 0.05% sodium azide. |
| Preservative | 0.05% Sodium Azide |
| Storage Temp. | This product is stable as shipped for a least one year when stored at ≤ -20° C. Avoid multiple freeze/thaw cycles by storage in appropriate aliquots. Do not store in a frost-free freezer. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.