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OX40/TNFRSF4 Antibody
SPA-10959
| Size | Price |
| 100 µL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | TNF receptor |
| Gene Abbr. | TNFRSF4 |
| Gene ID | 7293 |
| Full Name | TNF receptor superfamily member 4 |
| Alias | ACT35, CD134, IMD16, OX40, TXGP1L |
| Introduction | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | Ber-ACT35 |
| Isotype | IgG1 Kappa |
| Immunogen | HTLV 1-transformed HUT-102 cells. |
| Usage | |
|---|---|
| Application | WB, ELISA, FC, IHC, IP |
| Dilutions | Western Blot (1:100-1:2000); ELISA (1:100-1:2000); Flow Cytometry (1:10-1:1000); Immunohistochemistry (1:10-1:500); Immunoprecipitation (1:10-1:500) |
| Reactivity | Human, Primate |
| Specificity | The antibody MEM-258 recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS (pH 7.4). |
| Preservative | 15 mM Sodium Azide |
| Storage Temp. | Store at 4 °C. |
| Handling | Do not freeze. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.