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Noggin Sandwich ELISA Kit
SPK-00868
| Size | Price |
| 1 X 96T | Online Inquiry |
| 5 X 96T | Online Inquiry |
| 10 X 96T | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Noggin |
| Gene Abbr. | Nog |
| Gene ID | 18121 |
| Full Name | noggin |
| Introduction | Noggin is a secreted polypeptide which binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, it may have a principal role in creating morphogenic gradients. Noggin appears to have pleiotropic effect, both early in development as well as in later stages. The results of the mouse knockout of the ortholog suggest that noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse |
| Product Details | |
|---|---|
| Measurement | Sandwich |
| Usage | |
|---|---|
| Application | ELISA |
| Reactivity | |
| Assay Principle | quantitative |
| Sensitivity | 7.81 pg/mL |
| Detection Range | 31.25 pg/mL - 2000 pg/mL |
| Sample Volume | 50-100μL |
| Assay Time | 1-5h |
| Detection Wavelength | 450 nm |
| Precision | Intra-assay Precision (Precision within an assay): CV%<8%. Inter-assay Precision (Precision between assays): CV%<10%. |
| Storage & Handling | |
|---|---|
| Storage Temp. | Store at 2-8°C. Please refer to protocol. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.