Online Inquiry
Niraparib (MK-4827)
SPC-01486
CAS No. 1038915-60-4
| Size | Price |
| 5 mg | Online Inquiry |
| 10 mg | Online Inquiry |
| Bulk Size | Online Inquiry |
PARP inhibitor ; Apoptosis related activator
| Description |
|---|
| Niraparib (MK-4827) is a selective inhibitor of PARP1/2 with IC50 of 3.8 nM/2.1 nM, with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It is >330-fold selective against PARP3, V-PARP and Tank1. Niraparib can form PARP–DNA complexes resulting in DNA damage, apoptosis, and cell death. Phase 3. |
| Product Details | |
|---|---|
| CAS No. | CAS No. 1038915-60-4 |
| Description | Niraparib (MK-4827) is a selective inhibitor of PARP1/2 with IC50 of 3.8 nM/2.1 nM, with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It is >330-fold selective against PARP3, V-PARP and Tank1. Niraparib can form PARP–DNA complexes resulting in DNA damage, apoptosis, and cell death. Phase 3. |
| Formula | C19H20N4O |
| Molecular Weight | 320.39 |
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
| SMILES | C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N |
| Usage | |
|---|---|
| Storage | 3 years -20°C powder 2 years -80°C in solvent |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.