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MUTYH (-)/OGG1 (-) Cell Line
SPL-02200
| Size | Price |
| 1 Unit | Online Inquiry |
| Description |
|---|
| MUTYH (-)/OGG1 (-) |
| Target Information | |
|---|---|
| Target Name | MUTYH |
| Gene Abbr. | MUTYH |
| Gene ID | 4595 |
| Full Name | mutY DNA glycosylase |
| Alias | MYH |
| Species | Human |
| Introduction | This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]. |
| Product Details | |
|---|---|
| Cell Line Model | HAP1 |
| Genotype | MUTYH (-)/OGG1 (-) |
| Description | MUTYH (-)/OGG1 (-) |
| Parental Cell Line | C631 |
| Handling Specifications | |
|---|---|
| Disclaimer | This product is classified under IATA regulations as a GMMO (genetically modified micro-organism) and will ship as UN3245. If applicable, ensure facility meets all requirements per local and country regulations. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.