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MUC1 Antibody
SPA-07753
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | MUC1 |
| Gene Abbr. | MUC1 |
| Gene ID | 4582 |
| Full Name | mucin 1, cell surface associated |
| Alias | ADMCKD, ADMCKD1, CA 15-3, CD227, EMA |
| Introduction | Mucins represent a family of glycoproteins characterized by repeat domains and dense O-glycosylation. MUC1 (or mucin 1) is aberrantly overexpressed in most human carcinomas. Increased expression of MUC1 in carcinomas reduces cell-cell and cell-ECM interactions. MUC1 is cleaved proteolytically, and the large ectodomain can remain associated with the small 25 kDa carboxy-terminal domain that contains a transmembrane segment and a 72-residue cytoplasmic tail. MUC1 interacts with ErbB family receptors and potentiates ERK1/2 activation. MUC1 also interacts with β-catenin, which is regulated by GSK-3β, PKCγ, and Src through phosphorylation at Ser44, Thr41, and Tyr46 of the MUC1 cytoplasmic tail. Overexpression of MUC1 potentiates transformation and attenuates stress-induced apoptosis through the Akt or p53 pathways. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | VU4H5 |
| Immunogen | Produced by immunizing a BALB/c mouse with MUC1 60 mer tandem repeats (BSA conjugated). |
| Source/Purification | Antibody (isotype: IgG1k) is produced by immunizing a BALB/c mouse with MUC1 60 mer tandem repeats (BSA conjugated). |
| Usage | |
|---|---|
| Application | WB, IF, IHC, FC |
| Dilutions | Western Blot (1:1000) |
| MW(KDa) | 230, 400 |
| Reactivity | Human |
| Sensitivity | Endogenous |
| Specificity | It detects endogenous levels of total MUC1. This antibody does not cross-react with other mucin proteins. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. |
| Preservative | Less than 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Do not aliquot the antibody. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.