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MKK7 Antibody
SPA-07646
| Size | Price |
| 100 µL | Online Inquiry |
| 20 µL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | MKK7 |
| Gene Abbr. | MAP2K7 |
| Gene ID | 5609 |
| Full Name | mitogen-activated protein kinase kinase 7 |
| Alias | JNKK2, MAPKK7, MEK, MEK 7, MKK7 |
| Introduction | MKK7 is a MAP kinase kinase that serves as a specific activator of the SAPK/JNK pathway. MKK7 is strongly activated by TNF-α, as well as other environmental stresses, whereas SEK1/MKK4, which activates both p38 and SAPK/JNK pathways, is not activated by TNF-α. Sequence alignment of the activation loop of the MAP kinase kinase family members indicates that Ser271 and Thr275 are potential phosphorylation sites that are crucial for the kinase acivity. |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | E. coli-derived recombinant human MKK7. Met1-Arg419. O14733. |
| Usage | |
|---|---|
| Application | WB, IHC |
| Dilutions | Western Blot (2 µg/mL); Immunohistochemistry (5-15 µg/mL) |
| MW(KDa) | 48 |
| Reactivity | Human |
| Specificity | Detects human MKK7 in Western Blots. Does not cross-react with other recombinant human mitogen-activated protein kinase kinases. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.