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MKK6/MEK6 Antibody
SPA-07623
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | MKK6 |
| Gene Abbr. | MAP2K6 |
| Gene ID | 5608 |
| Full Name | mitogen-activated protein kinase kinase 6 |
| Alias | MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3 |
| Introduction | MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase. MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAPK/JNK. Phosphorylation of p38 MAP kinase dramatically stimulates its ability to phosphorylate protein substrates such as ATF-2 and Elk-1. MKK3 and MKK6 are both activated by different forms of cellular stress and inflammatory cytokines. Activation of MKK3 and MKK6 occurs through phosphorylation at Ser189 and Thr222 on MKK3 and Ser207 and Thr211 on MKK6. |
| Product Details | |
|---|---|
| Host | Rat |
| Clonality | Monoclonal |
| Clone No. | 304328 |
| Isotype | IgG2B |
| Immunogen | E. coli-derived recombinant human MKK6. Met1-Asp334. P52564.1. |
| Usage | |
|---|---|
| Application | WB, IF |
| Dilutions | Western Blot (0.5 µg/mL); Immunofluorescence (8-25 µg/mL) |
| MW(KDa) | 38 |
| Reactivity | Human, Mouse, Rat |
| Specificity | Detects human, mouse, and rat MKK6 in Western Blots. In Western Blots, no cross-reactivity with recombinant human MKK3 is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.