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MITF Antibody
SPA-07604
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | MITF |
| Gene Abbr. | MITF |
| Gene ID | 4286 |
| Full Name | melanocyte inducing transcription factor |
| Alias | CMM8, COMMAD, MI, WS2, WS2A |
| Introduction | Microphthalmia-associated transcription factor (MITF) is a basic helix-loop-helix leucine zipper transcription factor that is most widely known for its roles in melanocyte, ophthalmic, and osteoclast development. In humans, MITF can function as a melanoma oncogene and mutations in the corresponding MITF gene are associated with Waardenburg syndrome type 2, an auditory-pigmentary syndrome characterized by developmental defects in cells derived from neural crest. At least 12 isoforms of MITF have been identified, which exhibit differential patterns of expression among cell and tissue types. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | D5G7V |
| Immunogen | Synthetic peptide corresponding to residues surrounding Gly335 of human MITF protein. |
| Source/Purification | Antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly335 of human MITF protein. |
| Usage | |
|---|---|
| Application | WB, IP, ChIP |
| Dilutions | Western Blot (1:1000) |
| MW(KDa) | 50-75 |
| Reactivity | Human, Mouse, Rat, Hamster, Monkey |
| Sensitivity | Endogenous |
| Specificity | It recognizes endogenous levels of total MITF protein. The antibody is predicted to recognize all known isoforms of MITF. Based on sequence similarities and testing with exogenously expressed TFE3 samples, this antibody may also detect the related MiT/TEF protein family member TFE3. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. |
| Preservative | Less than 0.02% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Do not aliquot the antibody. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.