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MIB1 siRNA
SPR-01198
| Size | Price |
| 1 Unit | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | MIB1 |
| Gene Abbr. | MIB1 |
| Gene ID | 57534 |
| Full Name | mindbomb E3 ubiquitin protein ligase 1 |
| Alias | DIP-1, DIP1, LVNC7, MIB, ZZANK2 |
| Introduction | Mindbomb homolog 1 (MIB1) is an E3 ligase that facilitates the ubiquitination and the subsequent endocytosis of the Notch ligands, Delta and Jagged. MIB1 appears to promote the ubiquitination and degradation of death-associated protein kinase (DAPK1) in vitro. Expression of MIB1 is seen in both adult and embryonic murine tissues. Recently, MIB1 was reported to regulate the extrinsic cell death pathway by binding to cellular FLICE-like inhibitory proteins (cFLIP-L and cFLIP-S), which reduces the interaction of caspase-8 with cFLIP and leads to cell death. MIB1 is also involved in T and marginal zone B (MZB) cell development in the lymphopoietic niches. |
| Usage | |
|---|---|
| Application | RNA interference |
| Reactivity | |
| Storage & Handling | |
|---|---|
| Storage Buffer | The siRNA product is supplied in RNAse-free water. |
| Storage Temp. | Aliquot and store at -20 °C. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.