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LMNA cDNA ORF Clone, Human, In cloning vector
SPD-09522
| Size | Price |
| 1 Unit | Online Inquiry |
| Description |
|---|
| Full length Clone DNA of Human lamin A/C. |
| Target Information | |
|---|---|
| Species | Human |
| Target Name | Lamin A/C |
| Gene Abbr. | LMNA |
| Gene ID | 4000 |
| Full Name | lamin A/C |
| Alias | CDCD1, CDDC, CMD1A, CMT2B1, EMD2 |
| Introduction | Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization. Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment. The cleavage of lamins results in nuclear dysregulation and cell death. |
| Product Details | |
|---|---|
| Description | Full length Clone DNA of Human lamin A/C. |
| NCBI Ref Seq | NM_170707 |
| RefSeq ORF Size | 1995 bp |
| Sequence Information | Identical with the Gene Bank Ref. ID sequence except for two point mutations: 861 T/C and 1338 T/C not causing the amino acid variation. |
| Vector | pGEM-T Vector |
| Quality Control | The plasmid is confirmed by full-length sequencing. |
| Storage | The lyophilized plasmid can be stored at ambient temperature for three months. |
| Usage | |
|---|---|
| Sequencing Primers | SP6 and T7 or M13-47 and RV-M |
| Antibiotic in E.coli | Ampicillin |
| Shipping | Each tube contains lyophilized plasmid. |
| Storage | The lyophilized plasmid can be stored at ambient temperature for three months. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.