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KMT2A Knockout Cell Line
SPL-01845
| Size | Price |
| 1 Unit | Online Inquiry |
| Description |
|---|
| 32bp deletion |
| Target Information | |
|---|---|
| Target Name | KMT2A |
| Gene Abbr. | KMT2A |
| Gene ID | 4297 |
| Full Name | lysine methyltransferase 2A |
| Alias | ALL-1, CXXC7, HRX, HTRX1, MLL |
| Species | Human |
| Genomic Locus | chr11:118472433 |
| Introduction | This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]. |
| Product Details | |
|---|---|
| Cell Line Model | HAP1 |
| Genotype | KMT2A 32bp deletion knockout |
| Description | 32bp deletion |
| Parental Cell Line | C631 |
| Cell Number | 1x10^6 |
| Handling Specifications | |
|---|---|
| Culture Medium | IMDM + 10% FBS |
| Disclaimer | This product is classified under IATA regulations as a GMMO (genetically modified micro-organism) and will ship as UN3245. If applicable, ensure facility meets all requirements per local and country regulations. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.