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KDELR2 (-) Cell Line
SPL-01813
| Size | Price |
| 1 Unit | Online Inquiry |
| Description |
|---|
| KDELR2 (-) |
| Target Information | |
|---|---|
| Target Name | KDELR2 |
| Gene Abbr. | KDELR2 |
| Gene ID | 11014 |
| Full Name | KDEL endoplasmic reticulum protein retention receptor 2 |
| Alias | ELP-1, ERD2.2 |
| Species | Human |
| Introduction | Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]. |
| Product Details | |
|---|---|
| Cell Line Model | HAP1 |
| Genotype | KDELR2 (-) |
| Description | KDELR2 (-) |
| Parental Cell Line | C631 |
| Handling Specifications | |
|---|---|
| Disclaimer | This product is classified under IATA regulations as a GMMO (genetically modified micro-organism) and will ship as UN3245. If applicable, ensure facility meets all requirements per local and country regulations. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.