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ITGA11 cDNA ORF Clone, Human, In cloning vector
SPD-08808
| Size | Price |
| 1 Unit | Online Inquiry |
| Description |
|---|
| Full length Clone DNA of Human integrin, alpha 11. |
| Target Information | |
|---|---|
| Species | Human |
| Target Name | Integrin |
| Gene Abbr. | ITGA11 |
| Gene ID | 22801 |
| Full Name | integrin subunit alpha 11 |
| Alias | HsT18964 |
| Introduction | Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling).Integrin α1 (CD49a, VLA-1, ITGA1) pairs with integrin β1 to form an α1β1 dimer on the cell surface. This integrin dimer plays important roles in colorectal cancer and pancreatic cancer cell proliferation, migration, and metastasis. The cytoplasmic tail of integrin α1 activates ERK and FAK/Src signaling to promote these biological processes. |
| Product Details | |
|---|---|
| Description | Full length Clone DNA of Human integrin, alpha 11. |
| NCBI Ref Seq | NM_001004439.1 |
| RefSeq ORF Size | 3567 bp |
| Sequence Information | Identical with the Gene Bank Ref. ID sequence except for six point mutations: 1571 T/G resulting in the amino acid Leu substitution by Arg, 2915 C/T resulting in the amino acid Pro substitution by Leu, 651 C/T, 1317 G/A, 1677 C/T, 2583 A/G not causing the amino acid variation. |
| Vector | pMD18-T Simple Vector |
| Quality Control | The plasmid is confirmed by full-length sequencing. |
| Storage | The lyophilized plasmid can be stored at ambient temperature for three months. |
| Usage | |
|---|---|
| Sequencing Primers | M13-47 and RV-M |
| Antibiotic in E.coli | Ampicillin |
| Shipping | Each tube contains lyophilized plasmid. |
| Storage | The lyophilized plasmid can be stored at ambient temperature for three months. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.