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Integrin αV beta 3 Antibody
SPA-06246
| Size | Price |
| 100 µL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Integrin |
| Gene Abbr. | ITGAV |
| Gene ID | 3685 |
| Full Name | integrin subunit alpha V |
| Alias | CD51, MSK8, VNRA, VTNR |
| Introduction | Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling).Several αV subfamily members, including αVβ3, αVβ5, αVβ1, are highly expressed in active endothelial cells and cancer cells (3-6) where they play a critical role in angiogenesis and tumor metastasis. Therefore, interest has focused on αV integrin as a key therapeutic target in the treatment of cancer. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | VNR-1 |
| Isotype | IgG1 |
| Immunogen | This antibody is specific to Integrin Alpha VBeta 3. |
| Usage | |
|---|---|
| Application | IF, IHC, IP |
| Dilutions | Immunoprecipitation (1:10-1:500) |
| Reactivity | Human |
| Specificity | Reacts with the human integrin alphaVbeta3. Shown to be specific for alphaVbeta3 by Loftus JC et al (1990) Science 249:915-918. |
| Storage & Handling | |
|---|---|
| Storage Buffer | 20 mM Phosphate (pH 7.6) and 0.25 M NaCl. |
| Preservative | 0.1% Sodium Azide |
| Storage Temp. | Aliquot and store at -20 °C or -80 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.