Integrin αV beta 3 Antibody - CD BioSciences

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Integrin αV beta 3 Antibody

Integrin αV beta 3 Antibody

SPA-06244

Size Price
100 µL Online Inquiry
More Options Online Inquiry
Target Information
Target Name Integrin
Gene Abbr. ITGAV
Gene ID 3685
Full Name integrin subunit alpha V
Alias CD51, MSK8, VNRA, VTNR
Introduction Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling).Several αV subfamily members, including αVβ3, αVβ5, αVβ1, are highly expressed in active endothelial cells and cancer cells (3-6) where they play a critical role in angiogenesis and tumor metastasis. Therefore, interest has focused on αV integrin as a key therapeutic target in the treatment of cancer.
Product Details
Host Mouse
Clonality Monoclonal
Clone No. 23C6
Isotype IgG1
Immunogen A cell suspension containing osteoclasts from osteoclastomas.
Usage
Application FC, IHC, IP
Dilutions Flow Cytometry (2.5 μg/10^6 cells); Immunohistochemistry (1:10-1:500); Immunoprecipitation (1:10-1:500)
Reactivity Human
Storage & Handling
Storage Buffer PBS.
Preservative 0.02% Sodium Azide
Storage Temp. Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage.
Handling Avoid freeze-thaw cycles.

For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.