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Integrin αV beta 3 Antibody
SPA-06232
| Size | Price |
| 100 µg | Online Inquiry |
| 25 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Integrin |
| Gene Abbr. | ITGAV |
| Gene ID | 3685 |
| Full Name | integrin subunit alpha V |
| Alias | CD51, MSK8, VNRA, VTNR |
| Introduction | Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling).Several αV subfamily members, including αVβ3, αVβ5, αVβ1, are highly expressed in active endothelial cells and cancer cells (3-6) where they play a critical role in angiogenesis and tumor metastasis. Therefore, interest has focused on αV integrin as a key therapeutic target in the treatment of cancer. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 2549B |
| Isotype | IgG |
| Immunogen | Chinese Hamster Ovary cell line CHO-derived human Integrin alpha V beta 3. Human Integrin alpha V (Phe31-Val992) and Human Integrin beta 3 (Gly27-Asp718). Accession # NP_002201 and AAA52589. |
| Usage | |
|---|---|
| Application | FC |
| Dilutions | Flow Cytometry (0.25 μg/10^6 cells) |
| Reactivity | Human |
| Specificity | In ELISAs, it detects recombinant human Integrin alpha V beta 3 heterodimer, but does not detect recombinant human Integrin alpha V beta 1 and Integrin alpha 6 beta 1 heterodimers or recombinant human Integrin alpha V monomer. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.