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Integrin α6 beta 1 Antibody
SPA-06150
| Size | Price |
| 100 µg | Online Inquiry |
| 25 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Integrin |
| Gene Abbr. | ITGA6 |
| Gene ID | 3655 |
| Full Name | integrin subunit alpha 6 |
| Alias | CD49f, ITGA6B, VLA-6 |
| Introduction | Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling).Integrin α6 is a 120 kDa protein with two splice variants, integrin α6, 6A and 6B which function as receptors for laminins on the basal membrane to mediate cellular adhesion events. α6 integrins have been shown to play an important role in hematopoietic stem and progenitor cell homing to the bone marrow. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone No. | 2548B |
| Isotype | IgG |
| Immunogen | Chinese Hamster Ovary cell line, CHO-derived Human Integrin alpha 6 beta 1 heterodimer. Phe24-Ser1012(Integrin alpha 6) and Gln21-Asp728 (Integrin beta1). Accession # NP_000201. |
| Usage | |
|---|---|
| Application | FC |
| Dilutions | Flow Cytometry (0.25 μg/10^6 cells) |
| Reactivity | Human |
| Specificity | Detects human Integrin alpha 6 beta 1 in direct ELISAs. In direct ELISA, less than 1% of cross reactivity with recombinant human (rh) Integrin beta 1 and recombinant mouse (rm) Integrin alpha 6 is observed. In direct ELISA, no cross-reactivity with rhIntegrin alpha 3, beta 2, beta 3, beta 5, beta 6, beta 7, and rmIntegrin beta 1 is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.