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Integrin α6 Antibody
SPA-06155
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Integrin |
| Gene Abbr. | ITGA6 |
| Gene ID | 3655 |
| Full Name | integrin subunit alpha 6 |
| Alias | CD49f, ITGA6B, VLA-6 |
| Introduction | Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling).Integrin α6 is a 120 kDa protein with two splice variants, integrin α6, 6A and 6B which function as receptors for laminins on the basal membrane to mediate cellular adhesion events. α6 integrins have been shown to play an important role in hematopoietic stem and progenitor cell homing to the bone marrow. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 450-30A |
| Isotype | IgG1 |
| Immunogen | Alpha 6 beta 4 integrin purified from A431 cells. |
| Usage | |
|---|---|
| Application | WB, FC, IHC |
| Dilutions | Flow Cytometry (1:10-1:1000); Immunohistochemistry (1:10-1:500) |
| MW(KDa) | 150, 125 |
| Reactivity | Human |
| Specificity | Recognizes CD49f, also known as VLA-6 and alpha 6 integrin. CD49f is expressed by platelets, weakly by monocytes and by a subset of lymphocytes. CD49f is also widely expressed on epithelial tissues. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS (pH 7.4). |
| Preservative | 0.09% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.