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Integrin α5 beta 1 Antibody
SPA-06146
| Size | Price |
| 0.1 mL | Online Inquiry |
| 0.025 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Integrin |
| Gene Abbr. | ITGA5 |
| Gene ID | 3678 |
| Full Name | integrin subunit alpha 5 |
| Alias | CD49e, FNRA, VLA-5, VLA5A |
| Introduction | Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling).Integrin α5/β1 is involved in multiple biological processes including embryonic development, angiogenesis and tumor metastasis. By interaction with its fibronectin ligand, α5/β1 transduces signals that regulate cell adhesion, migration, matrix assembly and cytoskeletal organization. |
| Product Details | |
|---|---|
| Host | Rat |
| Clonality | Monoclonal |
| Clone No. | BMC5 |
| Isotype | IgG2B Kappa |
| Immunogen | Mouse embryonal carcinoma P19 cells with myeloma P3X63Ag9.653 cells. |
| Usage | |
|---|---|
| Application | WB, FC, IHC, IP |
| Dilutions | Flow Cytometry (10 µL/mL); Immunohistochemistry (1:10-1:500); Immunoprecipitation (2 µL) |
| MW(KDa) | 150 |
| Reactivity | Mouse |
| Specificity | Antibody was raised against mouse integrin VLA-5 (alpha5beta1), a fibronectin receptor. The antibody was prepared by fusion of spleen cells from a Fisher rat immunized with mouse embryonal carcinoma P19 cells with myeloma P3X63Ag9.653 cells. Cell lines tested to express alpha5beta1, include: P19 cells, mouse melanoma B16F1 cells, mouse squamous carcoma SCC cells and thymocytes. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Ascites. |
| Preservative | No Preservative |
| Storage Temp. | Aliquot and store at -20 °C or -80 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.