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Integrin α5 Antibody
SPA-06143
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Integrin |
| Gene Abbr. | ITGA5 |
| Gene ID | 3678 |
| Full Name | integrin subunit alpha 5 |
| Alias | CD49e, FNRA, VLA-5, VLA5A |
| Introduction | Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling).Integrin α5/β1 is involved in multiple biological processes including embryonic development, angiogenesis and tumor metastasis. By interaction with its fibronectin ligand, α5/β1 transduces signals that regulate cell adhesion, migration, matrix assembly and cytoskeletal organization. |
| Product Details | |
|---|---|
| Host | Sheep |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse Integrin alpha 5/CD49e. Phe45-Asn (Gln68Glu). Accession # P11688. |
| Usage | |
|---|---|
| Application | WB, FC |
| Dilutions | Western Blot (0.1 µg/mL); Flow Cytometry (0.25 µg/10^6 cells) |
| MW(KDa) | 150 |
| Reactivity | Mouse |
| Specificity | Detects mouse Integrin alpha 5/CD49e in direct ELISAs and Western Blots. In direct ELISAs, approximately 50% cross‑reactivity with recombinant human (rh) Integrin alpha 5 is observed, 15% cross‑reactivity with rhIntegrin alpha 2 and rhIntegrin alpha M is observed, and 5% cross‑reactivity with rhIntegrin alpha E is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.