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Integrin α2/CD49b Antibody
SPA-06068
| Size | Price |
| 100 µL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | Integrin |
| Gene Abbr. | ITGA2 |
| Gene ID | 3673 |
| Full Name | integrin subunit alpha 2 |
| Alias | BR, CD49B, GPIa, HPA-5, VLA-2 |
| Introduction | Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival. The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities. Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling).Integrin α1 (CD49a, VLA-1, ITGA1) pairs with integrin β1 to form an α1β1 dimer on the cell surface. This integrin dimer plays important roles in colorectal cancer and pancreatic cancer cell proliferation, migration, and metastasis. The cytoplasmic tail of integrin α1 activates ERK and FAK/Src signaling to promote these biological processes. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 16B4 |
| Isotype | IgG1 |
| Immunogen | Purified human beta 1 preparation from HT1080 fibrosarcoma cell extract. |
| Usage | |
|---|---|
| Application | ELISA, FC, IF, IHC, IP |
| Dilutions | ELISA (1:100-1:2000); Flow Cytometry (1:10-1:1000); Immunofluorescence (1:10-1:500); Immunohistochemistry (1:10-1:500); Immunoprecipitation (1:10-1:500) |
| Reactivity | Human |
| Specificity | 16B4 can be used to IP a non-reducible alpha subunit from I(125) surface labelled Human cell line extract. It is specific to the alpha 2 subunit by relative expression of antigen on various cell lines by FACS, and its recognition of affinity purified alpha 2 beta 1 in DB. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.