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IL-36 beta/IL-1F8 Antibody
SPA-05901
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | IL-36 |
| Gene Abbr. | IL36B |
| Gene ID | 27177 |
| Full Name | interleukin 36 beta |
| Alias | FIL1, FIL1-(ETA), FIL1H, FILI-(ETA), IL-1F8 |
| Introduction | Human interleukin 1 family member #8 [IL-1F8; also named Interleukin-36 beta, IL36B, FIL-1 eta (eta) and IL-1H2] is a member of the IL-1 family of proteins. IL-1 family members include IL‑1 beta, IL-1 alpha, IL-1ra, IL-18 and IL-1F5 through F10. All family members show a 12 beta -stranded beta -trefoil configuration, and are believed to have arisen from a common ancestral gene that has undergone multiple duplications. Two alternatively spliced transcript variants encode distinct (164 or 157 residues) protein isoforms that differ in their C-terminal 70 amino acid (aa) residues have been reported. IL-1F8 isoform 2 is synthesized as a 157 aa protein that contains no signal sequence and no prosegment. Unlike IL-1F8 isoform 1 which lacks potential N‑linked glycosylation sites, isoform 2 contains one potential N-linked glycosylation site in its unique C-terminus. IL-1F8 is reported to be actively secreted. |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | E. coli-derived recombinant human IL‑36 beta /IL‑1F8. Met1-Glu157. Q3MIH0. |
| Usage | |
|---|---|
| Application | WB, IHC |
| Dilutions | Western Blot (0.1 µg/mL); Immunohistochemistry (5-15 µg/mL); Neutralization (50-300 ng/mL) |
| Reactivity | Human |
| Specificity | Detects human IL‑36 beta /IL‑1F8 in direct ELISAs and Western Blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human(rh) IL-36 gamma and rhIL-36 alpha is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.