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IL-33 Antibody
SPA-05888
| Size | Price |
| 0.1 mg | Online Inquiry |
| 0.025 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | IL-33 |
| Gene Abbr. | IL33 |
| Gene ID | 90865 |
| Full Name | interleukin 33 |
| Alias | C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV |
| Introduction | Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine and intracellular nuclear factor with transcriptional regulatory properties. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | A portion of amino acids 50-100 of human IL-33 was used as the immunogen for this antibody. |
| Usage | |
|---|---|
| Application | WB |
| Dilutions | Western Blot (0.5-2 µg/mL) |
| Reactivity | Human, Canine, Primate |
| Specificity | 100% homologous in human (isoforms CRA_a and CRA_b). |
| Storage & Handling | |
|---|---|
| Storage Buffer | 0.2 mL PBS and 0.2% Gelatin. |
| Preservative | 0.05% Sodium Azide |
| Storage Temp. | Store at -20 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.