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IL-32 Antibody
SPA-05879
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | IL-32 |
| Gene Abbr. | IL32 |
| Gene ID | 9235 |
| Full Name | interleukin 32 |
| Alias | IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4 |
| Introduction | Interleukin-32 (IL-32) was initially identified as a transcript (NK4) that is selectively expressed in lymphocytes and NK cells and whose expression is increased following activation by IL-2. It was later re-isolated from an IL-18-treated lung carcinoma cell line and re-named IL-32. IL-32 is unusual in that it does not share sequence homology with known cytokine families and is highly expressed in immune tissues, existing in at least four differentially spliced isoforms. Because treatment of human monocytic and mouse macrophage cells with IL-32 induces several proinflammatory cytokines such as TNF-alpha, IL-8 and MIP-2, and because it is also induced in human peripheral lymphocyte cells after mitogen stimulation and in epithelial cells by IFNgamma, it has been suggested that IL-32 may play a role in autoimmune and inflammatory diseases such as rheumatoid arthritis. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | A peptide corresponding to 15 amino acids near the carboxy terminus of human IL-32. The immunogen is located within the last 50 amino acids of IL-32. Amino Acid Sequence: YGAPRGDKEELTPQK. |
| Usage | |
|---|---|
| Application | WB, ELISA, FC, IF, IHC, IF |
| Dilutions | Western Blot (0.5-4 µg/mL); ELISA (1:100-1:2000); Immunofluorescence (20 µg/mL); Immunohistochemistry (2-10 µg/mL); Immunofluorescence (20 µg/mL) |
| Reactivity | Human |
| Specificity | This antibody detects all isoforms of IL-32. Human IL-32 has 7 isoforms, including isoform 1 (234aa, 27kD), isoform 2 (188aa, 22kD), isoform 3 (178aa, 21kD), isoform 4 (131aa, 15kD), isoform 5 (168aa, 19kD), isoform 6 (179aa, 21kD) and isoform 7 (148aa, 17kD). This antibody can detect all human isoforms. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS. |
| Preservative | 0.02% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.