Online Inquiry
IL-20R alpha Antibody
SPA-05774
| Size | Price |
| 0.025 mg | Online Inquiry |
| 0.1 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | IL-20 Receptor |
| Gene Abbr. | IL20RA |
| Gene ID | 53832 |
| Full Name | interleukin 20 receptor subunit alpha |
| Alias | CRF2-8, IL-20R-alpha, IL-20R1, IL-20RA |
| Introduction | IL20R is a member of Cytokine Class II receptor super family. It consists of a central transmembrane domain and functionally induces IL20 and IL26 signaling in epithelial cells and keratinocytes. It associates with IL-20RB and forms a functional receptor complex for IL20, IL19, and IL24. It also associates with IL-10RB and forms a unique heterodimeric functional receptor complex for IL-26. Upon ligand binding, it induces signaling through activation of STAT3 and STAT1. IL20RA is specifically expressed in skin suggesting a prominent role in growth and proliferation of keratinocytes. |
| Product Details | |
|---|---|
| Host | Rabbit |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Amino acids 159-175 of human IL-20 receptor alpha protein were used as the immunogen. |
| Usage | |
|---|---|
| Application | WB, FC |
| Dilutions | Western Blot (1-3 µg/mL); Flow Cytometry (2-5 µg/10^6 cells) |
| Reactivity | Human, Mouse |
| Specificity | The amino acid sequence used as immunogen is 100% homologous in human and chimp, and 82% homologous in mouse and rat. Both the expect ~70 kD band and an unknown ~90 kD band are seen in A375 cell lysate and are blocked by the immunizing peptide. The ~90 kD band alone is seen in A431 cell lysate, and it is also blocked by the immunizing peptide. This antibody was made against a portion of the extracellular domain of IL-20RA. Permeabilization of the cells during testing may affect antibody binding. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS containing 0.2% gelatin. |
| Preservative | 0.05% Sodium Azide |
| Storage Temp. | Store at 4 °C for a short term. Aliquot and store at -20 °C for long-term storage. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.