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IL-1ra/IL-1F3/IL1RN Antibody
SPA-05983
| Size | Price |
| 100 µL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | IL1R Antagonist |
| Gene Abbr. | IL1RN |
| Gene ID | 3557 |
| Full Name | interleukin 1 receptor antagonist |
| Alias | DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3 |
| Introduction | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | E. coli-derived recombinant human IL‑1ra/IL-1F3. Arg26-Glu177. P18510. |
| Usage | |
|---|---|
| Application | WB |
| Dilutions | Western Blot (1 µg/mL); Neutralization (5-10 µg/mL) |
| Reactivity | Human |
| Specificity | Detects human IL‑1ra/IL-1F3 in direct ELISAs and Western Blots. In direct ELISAs, less than 10% cross-reactivity with recombinant mouse IL‑1ra/IL‑1F3, recombinant rat IL-1ra/IL-1F3, recombinant porcine IL‑1ra/IL-1F3, and recombinant equine IL‑1ra/IL-1F3 is observed, and less than 1% cross-reactivity with recombinant human (rh) IL-1a, rhIL-1b, rhIL-18, and rhIL-1H1 is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.