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IL-10 Antibody
SPA-05566
| Size | Price |
| 0.1 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | IL-10 |
| Gene Abbr. | IL10 |
| Gene ID | 3586 |
| Full Name | interleukin 10 |
| Alias | CSIF, GVHDS, IL-10, IL10A, TGIF |
| Introduction | The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. [provided by RefSeq] |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | E. coli-derived recombinant cotton rat IL‑10 (R&D Systems, Catalog # 581-CR). Ser1-Ser160 with a Cys149Tyr substitution. AAK94013. |
| Usage | |
|---|---|
| Application | WB |
| Dilutions | Western Blot (0.1 µg/mL) |
| Reactivity | D. melanogaster |
| Specificity | Detects cotton rat IL-10 in direct ELISAs and Western Blots. In direct ELISAs, approximately 45% cross-reactivity with recombinant rat IL‑10 is observed, 30% cross-reactivity with recombinant mouse IL-10 is observed, and 5% cross-reactivity with recombinant canine IL‑10, recombinant human IL‑10, and recombinant porcine IL‑10 is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.