Online Inquiry
IL-10 Antibody
SPA-05559
| Size | Price |
| 0.1 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | IL-10 |
| Gene Abbr. | IL10 |
| Gene ID | 3586 |
| Full Name | interleukin 10 |
| Alias | CSIF, GVHDS, IL-10, IL10A, TGIF |
| Introduction | The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. [provided by RefSeq] |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 148801 |
| Isotype | IgG2B |
| Immunogen | E. coli-derived recombinant porcine IL-10. Ser19-Asn175. Q29055. |
| Usage | |
|---|---|
| Application | Neutralization |
| Dilutions | Neutralization (0.05-0.15 µg/mL) |
| Reactivity | Porcine |
| Specificity | Detects porcine IL‑10 in direct ELISAs. In direct ELISAs, 25-50% cross-reactivity with recombinant feline IL-10, recombinant canine IL-10, and recombinant guinea pig IL-10 is observed, approximately 10% cross-reactivity with recombinant human IL-10 is observed, less than 5% cross-reactivity with recombinant cotton rat IL-10 is observed, and no cross-reactivity with recombinant equine IL-10, recombinant mouse IL-10, recombinant rat IL-10, or recombinant viral IL-10 is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.