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IL-1 RI Antibody
SPA-05542
| Size | Price |
| 0.05 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | IL-1 Receptor |
| Gene Abbr. | IL1R1 |
| Gene ID | 3554 |
| Full Name | interleukin 1 receptor type 1 |
| Alias | CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA |
| Introduction | The Interleukin 1 receptor type I (IL-1R1) belongs to the IL-1 receptor family. IL-1R1 binds to IL-1 alpha, IL-1 beta, and interleukin-1 receptor antagonist protein (IL-1RA). IL-1RA regulates IL-1 ligand biological activity by a competitive interaction for IL-1R1. Upon IL-1 stimulation, adaptor molecule MyD88 is first recruited to the IL-1R1-IL1R accessory protein complex, followed by the recruitment of two serine-threonine kinases, IRAK4 and IRAK, and the adaptor protein TRAF6, resulting in activation of the NF-kB pathway. Stimulation of IL-1R1, leads to activation of the transcription factors NF-B, ATF, and AP-1. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 40101 |
| Isotype | IgG2B |
| Immunogen | The extracellular domain of the type I human IL-1 receptor. |
| Usage | |
|---|---|
| Application | WB, ELISA, IHC, WB |
| Dilutions | ELISA (1:100-1:2000) |
| Reactivity | Human, Sheep |
| Specificity | These antibodies react with cell surface and soluble human IL-1 receptor; Specific epitopes are unknown, but they do partially inhibit (30-50%) binding of one another to IL-1 receptor. They do not block binding of IL-1 to receptor, and they do not cross-react with receptors for human IL-2 or IL-4. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS (pH 7.4), sourced in Ascites. |
| Preservative | No Preservative |
| Storage Temp. | Aliquot and store at -20 °C or -80 °C. |
| Handling | Avoid freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.