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IL-1 beta/IL-1F2 Antibody
SPA-05522
| Size | Price |
| 0.1 mg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | IL-1 |
| Gene Abbr. | IL1B |
| Gene ID | 3553 |
| Full Name | interleukin 1 beta |
| Alias | IL-1, IL1-BETA, IL1F2, IL1beta |
| Introduction | IL-1 is a name that designates two proteins, IL-1 alpha and IL-1 beta, that are the products of distinct genes, but recognize the same cell surface receptors. IL-1 alpha and IL-1 beta are structurally related polypeptides that show approximately 25% homology at the amino acid level. Both proteins are produced by a wide variety of cells in response to stimuli such as those produced by inflammatory agents, infections, or microbial endotoxins. The proteins are synthesized as 31 kDa precursors that are subsequently cleaved into proteins with molecular weights of approximately 17.5 kDa. The specific protease responsible for the processing of IL-beta, designated interleukin 1 beta -converting enzyme (ICE), has been described. Mature human and mouse IL-1 beta share approximately 75% amino acid sequence identity and human IL-1 beta has been found to be active on murine cell lines. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | 11E5 |
| Isotype | IgG2B |
| Immunogen | Hybridoma clone has been derived from hybridization of X63.Ag8.653 myeloma cells with spleen cells of Balb/c mice immunized with recombinant human IL-1, beta. |
| Usage | |
|---|---|
| Application | IHC |
| Dilutions | Immunohistochemistry (1:10-1:500); ELISA (1:100-1:2000) |
| Reactivity | Human |
| Specificity | Reacts with three different determinants on IL-1, beta molecule. It does not inhibit the biological activity of IL-1. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS (pH 7.4). |
| Preservative | 0.09% Sodium Azide |
| Storage Temp. | Store at 4 °C. |
| Handling | Do not freeze. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.