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IGF-II R/IGF2R Antibody
SPA-05421
| Size | Price |
| 0.025 mL | Online Inquiry |
| 0.1 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | IGF Receptor |
| Gene Abbr. | IGF2R |
| Gene ID | 3482 |
| Full Name | insulin like growth factor 2 receptor |
| Alias | CD222, CI-M6PR, CIMPR, M6P-R, M6P/IGF2R |
| Introduction | The Cation independent Mannose 6 Phosphate Receptor transports phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose 6 phosphate receptors in the Golgi apparatus and the resulting receptor ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | MEM-238 |
| Isotype | IgG1 |
| Immunogen | Recombinant Vaccinia virus encoding CD222. |
| Usage | |
|---|---|
| Application | WB, FC, IP |
| Dilutions | Western Blot (1:1000); Flow Cytometry (1-2 µg/mL); Immunoprecipitation (1:10-1:500) |
| Reactivity | Human, Primate |
| Specificity | The antibody MEM-238 recognizes an epitope between domains 2 and 5 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal ompartment, 5-10% in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum. |
| Storage & Handling | |
|---|---|
| Storage Buffer | PBS (pH 7.4). |
| Preservative | 15 mM Sodium Azide |
| Storage Temp. | Store at 4 °C. |
| Handling | Do not freeze. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.