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HER4/ErbB4 Antibody
SPA-05049
| Size | Price |
| 25 µg | Online Inquiry |
| 100 µg | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | HER4/ErbB4 |
| Gene Abbr. | ERBB4 |
| Gene ID | 2066 |
| Full Name | erb-b2 receptor tyrosine kinase 4 |
| Alias | ALS19, HER4, p180erbB4 |
| Introduction | Research studies have implicated the HER/ErbB receptor tyrosine kinase family in normal development, cardiac function and cancer. HER4/ErbB4, like other family members, has four ectodomains, a single transmembrane domain and a cytoplasmic tail containing the active tyrosine kinase domain. By binding to neuregulins and/or EGF family ligands, ErbB4 forms either a homodimer or heterodimer with other ErbB family members, which results in receptor activation and signaling. ErbB4 is ubiquitously expressed with the highest expression occurring in brain and heart. The expression of ErbB4 in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in research studies suggesting that ErbB4 expression is involved in both normal tissue development and carcinogenesis. |
| Product Details | |
|---|---|
| Host | Goat |
| Clonality | Polyclonal |
| Clone No. | N/A |
| Isotype | IgG |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human ErbB4/Her4. Gln26-Arg649. Accession # Q15303. |
| Usage | |
|---|---|
| Application | WB, FC, IF |
| Dilutions | Western Blot (0.1 µg/mL); Flow Cytometry (2.5 µg/10^6 cells); Immunofluorescence (5-15 µg/mL) |
| MW(KDa) | 180 |
| Reactivity | Human |
| Specificity | Detects human ErbB4/Her4 in direct ELISAs and Western Blots. In direct ELISAs, approximately 25% cross‑reactivity with recombinant mouse ErbB4 is observed, and less than 1% cross-reactivity with recombinant human (rh) ErbB2, rhErbB3, and rhEGF R is observed. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.