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GSK-3β Antibody
SPA-04892
| Size | Price |
| 0.025 mL | Online Inquiry |
| 0.1 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | GSK-3 |
| Gene Abbr. | GSK3B |
| Gene ID | 2932 |
| Full Name | glycogen synthase kinase 3 beta |
| Introduction | Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization. |
| Product Details | |
|---|---|
| Host | Rat |
| Clonality | Monoclonal |
| Clone No. | 272536 |
| Isotype | IgG2B |
| Immunogen | E. coli-derived recombinant human GSK-3 beta. Met1-Thr420. P49841. |
| Usage | |
|---|---|
| Application | WB, FC, IF |
| Dilutions | Western Blot (1 µg/mL); Immunofluorescence (3-25 µg/mL); Flow Cytometry (2.5 µg/10^6 cells) |
| MW(KDa) | 46 |
| Reactivity | Human, Mouse, Rat |
| Specificity | Detects human, mouse, and rat GSK-3 beta in ELISAs and Western Blots. Does not cross-react with recombinant human GSK-3 alpha. |
| Storage & Handling | |
|---|---|
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. |
| Preservative | No Preservative |
| Storage Temp. | 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Handling | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.