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GnRHR Antibody
SPA-04570
| Size | Price |
| 0.05 mL | Online Inquiry |
| More Options | Online Inquiry |
| Target Information | |
|---|---|
| Target Name | GnRHR |
| Gene Abbr. | GNRHR |
| Gene ID | 2798 |
| Full Name | gonadotropin releasing hormone receptor |
| Alias | GNRHR1, GRHR, HH7, LHRHR, LRHR |
| Introduction | GnRHR is a Releasing-Hormone Receptor activated by gonadotropin-releasing hormone (GnRH). This receptor plays a major role in the regulation of reproductive functions. It modulates the synthesis and secretion of gonadotropin hormones such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary. In turn, LH and FSH regulate the release of steroid hormones from the gonads. Mutations in GnRHR have been linked to hypogonadotropic hypogonadism, a condition characterized by absence or delayed puberty and retarded bone maturation. GnRHR has been reported to be expressed mostly in the pituitary gonadotropes and in reproductive organs, including ovary, placenta, prostate, testis, and uterus. It is also expressed in breast, heart, kidney, liver, skeletal muscle, and thymus. No human |
| Product Details | |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone No. | F1G4 |
| Isotype | IgG1 Kappa |
| Immunogen | A synthetic peptide aa 1-29 (MANSASPEQNQHCSAINNSIPLMQGNLPY) from the N-terminal of human GnRH receptor. |
| Usage | |
|---|---|
| Application | WB, FC, IHC, IF |
| Dilutions | Flow Cytometry (0.5-1 µg/10^6 cells in 0.1 mL); Immunofluorescence (1-2 µg/mL) |
| Reactivity | Human, Rat, Porcine, Rabbit |
| Specificity | Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations. |
| Storage & Handling | |
|---|---|
| Storage Buffer | 10 mM PBS with 0.05% BSA. |
| Preservative | 0.05% Sodium Azide |
| Storage Temp. | Store at 4 °C. |
For research use only. Not intended for any clinical use. No products from CD BioSciences may be resold, modified for resale or used to manufacture commercial products without prior written approval from CD BioSciences.